期刊
BIOCHEMICAL SOCIETY TRANSACTIONS
卷 34, 期 -, 页码 837-841出版社
PORTLAND PRESS LTD
DOI: 10.1042/BST0340837
关键词
docking site; mitogen-activated protein kinase (MAR); scaffold protein; Ste7; yeast
资金
- NIGMS NIH HHS [GM69013, GM60366, R33 GM069013, R21 GM069013, R01 GM060366, R01 GM060366-06, GM75309, R01 GM075309] Funding Source: Medline
MAPK (mitogen-activated protein kinase) signalling pathways contribute to the regulation of diverse responses, including normal and pathological aspects of cell growth, division, differentiation and death. Their ubiquity and versatility raise the issue of how they achieve specific coupling of signal with cellular response. How do the kinases in the cascade distinguish their correct substrates from the vast excess of incorrect substrates? Furthermore, how do different signals elicit distinct responses when they are transmitted by the same components? This short review highlights several mechanisms that can promote specificity in MAPK signalling, including tethering interactions between MAPKs and their substrates and regulators mediated by docking sites, feedback loops and cross-pathway regulatory circuits, and the selective activation of scaffold proteins.
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