期刊
TRENDS IN BIOCHEMICAL SCIENCES
卷 31, 期 11, 页码 604-607出版社
ELSEVIER SCIENCE LONDON
DOI: 10.1016/j.tibs.2006.09.003
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资金
- NIDDK NIH HHS [DK074192] Funding Source: Medline
- NIGMS NIH HHS [GM41840] Funding Source: Medline
Copper is essential for biological processes such as free radical detoxification, mitochondrial respiration and iron metabolism. A central player in copper homeostasis is the high-affinity integral plasma membrane copper transporter Ctr1. However, the precise mechanisms by which Ctr1 functions are not known. Here, we highlight an important breakthrough in our understanding of how Ctr1 facilitates CO) movement across membranes: the publication of structural details for human Ctr1 obtained from 2D crystallography and electron microscopy.
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