期刊
JOURNAL OF CLINICAL NEUROSCIENCE
卷 13, 期 9, 页码 934-938出版社
ELSEVIER SCI LTD
DOI: 10.1016/j.jocn.2005.10.018
关键词
astrocytes; glial fibrillary acidic protein; hippocampus; excitotoxicity; kainate; seizures; traumatic brain injury
Astrocytes perform a variety of functions in the adult central nervous system. Recent evidence suggests that the upregulation of glial fibrillary acidic protein (GFAP), an astrocyte-specific intermediate filament component, is a biological marker of neurotoxicity after cerebral injury. We herein compared the response to traumatic brain injury or kainic acid (KA)-induced neurotoxicity in GFAP knockout (GFAP-KO) and wild-type (WT) mice. Seventy-two hours after injury, all GFAP-KO mice showed hippocampal CA3 neurodegeneration, whereas WT mice did not show neurodegeneration. Seventy-two hours after KA administration, GFAP-KO mice were more susceptible to KA-induced seizures and had an increased number of pyknotic damaged CA3 neurons than did WT mice. These results indicate that GFAP plays a crucial role in pyramidal neuronal survival after injury or KA-induced neurotoxicity. (C) 2006 Elsevier Ltd. All rights reserved.
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