期刊
JOURNAL OF LABELLED COMPOUNDS & RADIOPHARMACEUTICALS
卷 49, 期 13, 页码 1163-1170出版社
WILEY
DOI: 10.1002/jlcr.1133
关键词
organo-germanium compound; spleen imaging agent; 99Tc-complex
Tc-99m-Labeled organo-germanium nanoparticles ranging in size from 60 to 80 nm were newly developed for a spleen imaging agent. The radiolabeled nanoparticles were prepared with a high labeling efficiency (over 99%) and they also showed an excellent stability at room temperature for 6 h. The biodistribution data of the nanoparticles injected into rats via intravenous routes showed a notably higher accumulation in the spleen when compared to other reticuloendothelial system organs. Gamma image of the rabbits obtained after an intravenous injection of the nanoparticles revealed a localization of the radioactivity mainly in the spleen and the liver. Copyright (c) 2006 John Wiley & Sons, Ltd.
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