期刊
DIABETES-METABOLISM RESEARCH AND REVIEWS
卷 22, 期 6, 页码 437-443出版社
WILEY
DOI: 10.1002/dmrr.666
关键词
alanine aminotransferase; fatty liver; epidemiology; type 2 diabetes mellitus; cardiovascular disease
For a long time, hepatic steatosis was believed to be a benign condition. Only recently, liver steatosis, also termed non-alcoholic fatty liver disease (NAFLD), has gained much interest. In most cases of NAFLD, a condition regarded as the hepatic component of the metabolic syndrome, the enzyme alanine. aminotransferase (ALT) is elevated and consequently has been used as a marker for NAFLD. More recently, several cross-sectional and prospective studies have demonstrated associations of this liver enzyme with features of the metabolic syndrome and type 2 diabetes mellitus. This review discusses the biochemical and metabolic properties of ALT, its applicability as a marker of NAFLD and describes its possible role in the pathogenesis of the metabolic syndrome and type 2 diabetes mellitus and subsequent cardiovascular disease. In addition, treatment strategies to ameliorate NAFLD and the associated risks are discussed. Copyright (c) 2006 John Wiley & Sons, Ltd.
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