期刊
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE
卷 1762, 期 11-12, 页码 973-985出版社
ELSEVIER SCIENCE BV
DOI: 10.1016/j.bbadis.2006.08.001
关键词
complex disease; complex genetic; amyotrophic lateral sclerosis; sporadic; association study; gene; genetic
In complex diseases like ALS, there are multiple genetic and environmental factors all contributing to disease liability. The genetic factors causing susceptibility to developing ALS can be considered a spectrum from single genes with large effect sizes causing classical Mendelian ALS, to genes of smaller effect, producing apparently sporadic disease. We examine the statistical genetic principles that underpin this model and review what is known about ALS as a disease with complex genetics. (c) 2006 Published by Elsevier B.V.
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