期刊
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH
卷 1763, 期 11, 页码 1147-1160出版社
ELSEVIER
DOI: 10.1016/j.bbamcr.2006.08.050
关键词
calcium channel; TRP channel; Stim 1; Orai 1; calcium-release-activated-calcium current; store-operated channel; capacitative calcium entry; calcium oscillation
Depletion of intracellular Ca2+ stores induces Ca2+ influx across the plasina membrane through store-operated channels (SOCs). This store-operated Ca2+ influx is important for the replenishment of the Ca2+ stores, and is also involved in many signaling processes by virtue of the ability of intracellular Ca2+ to act as a second messenger. For many years, the molecular identities of particular SOCs, as well as the signaling mechanisms by which these channels are activated, have been elusive. Recently, however, the mammalian proteins STIM1 and Orai1 were shown to be necessary for the activation of store-operated Ca2+ entry in a variety of mammalian cells. Here we present molecular, pharmacological, and electrophysiological properties of SOCs, with particular focus on the roles that STIM1and Orai1may play in the signaling processes that regulate various pathways of store-operated entry. Published by Elsevier B.V.
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