Visfatin concentration in Asian Indians is correlated with high density lipoprotein cholesterol and apolipoprotein A1

Background Visfatin is a recently described adipose tissue derived hormone whose role in humans remains largely unknown. Objectives To determine visfatin's relationship to lipoproteins and body composition parameters in Asian Indians and Caucasians. Design A cross-sectional study. Patients Men and women living in Montreal, Canada between the ages of 20 and 60 years were recruited for participation in this study. Subjects were excluded if they had a history of CVD or were taking lipid lowering medication. Individuals identified themselves as Asian Indian or Caucasian. Measurements Anthropometric measurements were collected including weight, height, waist circumference, hip circumference and body fat percentage (BF%). Serum samples were analysed for total cholesterol, HDL-C, apoA1, apoB and visfatin. Results There was no difference in visfatin levels between Indian and Caucasian men (64.50 +/- 3.98 ng/ml vs 73.01 +/- 6.45 ng/ml, ns, respectively) and Indian and Caucasian women (59.03 +/- 5.71 ng/ml vs 77.70 +/- 7.63 ng/ml, ns, respectively), despite large differences in BF%, apoB and the apoB/apoA1 ratio. Visfatin correlated positively to HDL-C and apoA1 in the Indian men (R = 0.42, P = 0.004 and R = 0.48, P = 0.003) and Indian women (R = 0.46, P = 0.05 and R = 0.59, P = 0.01). Conclusion Visfatin concentrations may be related to HDL metabolism in Asian Indian immigrants.