期刊
DEVELOPMENTAL DYNAMICS
卷 235, 期 11, 页码 3132-3143出版社
WILEY
DOI: 10.1002/dvdy.20950
关键词
myogenesis; muscle growth; hyperplasia; fibre type; mef2D; Pax7; evolution; fish muscle
Present knowledge indicates that fibre recruitment (hyperplasia) in developing teleost fish occurs in three distinct phases. However, the origin and relationship of the myogenic precursors activated during the different phases remains unclear. Here, we address this issue using molecular techniques on embryos and larvae of pearlfish, a large cyprinid species. Results provide comprehensive molecular characterisation of cell recruitment over the three phases of myogenesis, identifying muscle types as they arise. Specifically, we show that the myogenic cells arising during 2nd phase myogenesis are clearly different from the myogenic cells arising during the 3rd phase and that the dermomyotome is a major source of myogenic cells driving 2nd phase hyperplasia. These findings are discussed in relation to their implications for the generality of vertebrate developmental patterns.
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