期刊
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
卷 50, 期 11, 页码 3905-3907出版社
AMER SOC MICROBIOLOGY
DOI: 10.1128/AAC.00522-06
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Proton pump inhibitor treatment of clindamycin-treated mice elevated the gastric pH and facilitated the establishment of colonization of the large intestine by vancomycin-resistant Enterococcus spp. (75 to 80%, versus 20 to 25% for saline-treated controls) and Klebsiella pneumoniae (90%, versus 30% for saline-treated controls). These findings demonstrate a mechanism by which proton pump inhibitor therapy could contribute to the dissemination of nosocomial pathogens.
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