期刊
BRITISH JOURNAL OF HAEMATOLOGY
卷 135, 期 3, 页码 405-407出版社
BLACKWELL PUBLISHING
DOI: 10.1111/j.1365-2141.2006.06295.x
关键词
pure red cell aplasia; erythropoiesis; thymoma
类别
Acquired pure red cell aplasia (PRCA) is a rare disorder of erythropoiesis that can develop in association with a thymoma. Optimal management of this subgroup is unclear, and there have been few series reporting long-term clinical outcomes. Here, we report features of 13 patients treated for PRCA associated with thymoma over 50 years at our institution. Surgical resection of the thymoma was insufficient for normalisation of erythropoiesis in all cases. T-cell gene rearrangement studies did not routinely demonstrate a clonal process, and ciclosporin and anti-thymocyte globulin were effective adjuvant treatments. However, treatment-related morbidity was high, with frequent infectious complications.
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