期刊
JOURNAL OF PHARMACOLOGICAL SCIENCES
卷 102, 期 3, 页码 347-353出版社
JAPANESE PHARMACOLOGICAL SOC
DOI: 10.1254/jphs.SCE06001X
关键词
adrenoceptor antagonist; calcium channel blocker; electrical stimulation
The influence of direct single pulse and subtetanic electrical stimulation (ES) on isolated rat hemidiaphragm response to adrenoceptor antagonists and calcium channel blockers was investigated. Muscle contractility was stimulated by cumulative micromolar noradrenaline. Noradrenaline effects on developed tension (Td) in the presence of various alpha- and beta-adrenoceptor antagonists (e.g., prazosin and ICI 118551) were qualitatively different during different types of ES. Also, intact L-voltage calcium channels were necessary for noradrenaline-induced potentiation of Td during both types of ES, while the balance between ryanodine receptors- and inositol triphosphate (IP3)-related calcium events in the muscle was influenced by the pattern of the ES.
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