期刊
NATURE STRUCTURAL & MOLECULAR BIOLOGY
卷 13, 期 11, 页码 1026-1028出版社
NATURE PUBLISHING GROUP
DOI: 10.1038/nsmb1159
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In Escherichia coli, the ATP-dependent DNA translocase FtsK transports DNA across the site of cell division and activates recombination by the XerCD recombinases at a specific site on the chromosome, dif, to ensure the last stages of chromosome segregation. DNA transport by FtsK is oriented by 8-base-pair asymmetric sequences ('KOPS'). Here we provide evidence that KOPS promote FtsK loading on DNA and that translocation is oriented at this step.
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