期刊
TRENDS IN PHARMACOLOGICAL SCIENCES
卷 27, 期 11, 页码 594-601出版社
ELSEVIER SCIENCE LONDON
DOI: 10.1016/j.tips.2006.09.005
关键词
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资金
- NIAID NIH HHS [R37 AI050234, R01 AI050234, R01 AI050234-07, R01 AI 50234] Funding Source: Medline
The ability to treat and control Plasmodium falciparum infection through chemotherapy has been compromised by the advent and spread of resistance to antimalarial drugs. Research in this area has identified the P. falciparum chloroquine resistance transporter (PfCRT) and the multidrug resistance-1 (PfMDR1) transporter as key determinants of decreased in vitro susceptibility to several principal antimalarial drugs. Transfection-based in vitro studies are consistent with clinical findings of an association between mutations in the pfcrt gene and failure of chloroquine treatment, and between amplification of the pfmdr1 gene and failure of mefloquine treatment. Many countries are now switching to artemisinin-based combination therapies. These incorporate partner drugs of which some have an in vitro efficacy that can be modulated by changes in pfcrt or pfmdr1. Here, we summarize investigations of these and other recently identified P. faiciparum transporters in the context of antimalarial mode of action and mechanisms of resistance.
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