It has been argued that the bosonic sectors of supersymmetric SU(N) Yang-Mills theory, and of QCD with a single fermion in the antisymmetric (or symmetric) tensor representation, are equivalent in the N ->infinity limit. If true, this correspondence can provide useful insight into properties of real QCD (with fundamental representation fermions), such as predictions [with O(1/N) corrections] for the nonperturbative vacuum energy, the chiral condensate, and a variety of other observables. Several papers asserting to have proven this large N orientifold equivalence have appeared. By considering theories compactified on R(3)xS(1), we show explicitly that this large N equivalence fails for sufficiently small radius, where our analysis is reliable, due to spontaneous symmetry breaking of charge-conjugation symmetry in QCD with an antisymmetric (or symmetric) tensor representation fermion. This theory is also chirally symmetric for small radius, unlike super-Yang-Mills theory. The situation is completely analogous to large-N equivalences based on orbifold projections: simple symmetry realization conditions are both necessary and sufficient for the validity of the large N equivalence. Whether these symmetry realization conditions are satisfied depends on the specific nonperturbative dynamics of the theory under consideration. Unbroken charge-conjugation symmetry is necessary for validity of the large N orientifold equivalence. Whether or not this condition is satisfied on R-4 (or R(3)xS(1) for sufficiently large radius) is not currently known.
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