期刊
EXPERT REVIEW OF MOLECULAR DIAGNOSTICS
卷 6, 期 6, 页码 857-864出版社
TAYLOR & FRANCIS AS
DOI: 10.1586/14737159.6.6.857
关键词
culture; DFA; epidemiology; paired and single serology; PCR; sensitivity; specificity; symptoms
类别
The accurate and timely diagnosis of pertussis continues to be challenging. The widespread use of pertussis vaccines has dramatically altered the epidemiology and clinical presentation of pertussis disease, such that many cases do not present with the hallmark symptoms, such as inspiratory whoop, post-tussive vomiting and paroxysmal cough. A variety of laboratory tools are available to aid in the diagnosis of pertussis, including culture, direct fluorescent antibody testing, PCR, and paired and single serology techniques. This article reviews the strengths and limitations, including the sensitivity and specificity of each of these diagnostic tools.
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