期刊
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
卷 16, 期 21, 页码 5598-5601出版社
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.bmcl.2006.08.089
关键词
HIF-1 alpha prolyl hydroxylase inhibitors; imidazo[1,2-a]pyridines
Utilizing modeling information from a recently resolved structure of human HIF-1 alpha prolyl hydroxylase (EGLN1) and structure-based design, a novel series of imidazo[1,2-a]pyridine derivatives was prepared. The activity of these compounds was determined in a human EGLN1 assay and a limited SAR was developed. (c) 2006 Elsevier Ltd. All rights reserved.
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