4.7 Article

A slow-release system of bacterial cellulose gel and nanoparticles for hydrophobic active ingredients

期刊

INTERNATIONAL JOURNAL OF PHARMACEUTICS
卷 486, 期 1-2, 页码 217-225

出版社

ELSEVIER
DOI: 10.1016/j.ijpharm.2015.03.068

关键词

Bacterial cellulose gel; Nanoparticles; Block copolymer; Biocompatibility; Drug delivery system; Retinol

资金

  1. CNRS, France
  2. PolyNat Carnot Institute, France
  3. LabEx ARCANE, France [ANR-11-LABX-0003-01]
  4. Institute of National Colleges of Technology, Japan

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A combination of bacterial cellulose (BC) gel and amphiphilic block copolymer nanoparticles was investigated as a drug delivery system (DDS) for hydrophobic active ingredients. Poly(ethylene oxide)-bpoly( caprolactone) (PEO-b-PCL) and retinol were used as the block copolymer and hydrophobic active ingredient, respectively. The BC gel was capable of incorporating copolymer nanoparticles and releasing them in an acetic acid-sodium acetate buffer solution (pH 5.2) at 37 degrees C. The percentage of released copolymer reached a maximum value of approximately 60% after 6 h and remained constant after 24 h. The percentage of retinol released from the copolymer-containing BC gel reached a maximum value at 4 h. These results show that the combination of BC gel and nanoparticles is a slow-release system that may be useful in the cosmetic and biomedical fields for skin treatment and preparation. (C) 2015 Elsevier B.V. All rights reserved.

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