期刊
BIOCHEMICAL SOCIETY TRANSACTIONS
卷 34, 期 -, 页码 919-921出版社
PORTLAND PRESS LTD
DOI: 10.1042/BST0340919
关键词
calcium signalling; reactive oxygen species; redox regulation; ryanodine receptor; sarcoplasmic reticulum; thiol modification
资金
- Wellcome Trust Funding Source: Medline
The RyR (ryanodine receptor)/calcium release channel contains a number of highly reactive thiol groups that endow it with redox sensitivity. in general, oxidizing conditions favour channel opening, while reducing conditions have the opposite effect. Thiol modification affects the channel sensitivity to its principal effectors, Ca2+, Mg2+ and ATP, and alters RyR protein interactions. Here, we give a brief account of the major findings and prevailing views in the field.
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