期刊
INTERNATIONAL JOURNAL OF CANCER
卷 119, 期 9, 页码 2071-2077出版社
WILEY-BLACKWELL
DOI: 10.1002/ijc.22077
关键词
Jagged-1; prostate cancer; cell growth; S phase
类别
资金
- NCI NIH HHS [5R01CA0803695] Funding Source: Medline
Notch is an ancient cell signaling system that regulates cell fate specification, stem cell maintenance and initiation of differentiation in many tissues. It has been reported that Jagged-1, a Notch ligand, is significantly over expressed in metastatic prostate cancer compared to localized prostate cancer or benign prostatic tissues. Therefore, deregulation of Jagged-1 protein levels may play a role in prostate cancer cell growth and progression. Hence, the aim of our current study was to investigate the mechanistic role of Jagged-1 in prostate cancer cell growth and cell cycle progression. Our results show, for the first time, that down-regulation of Jagged-1 induces cell growth inhibition and S phase cell cycle arrest in prostate cancer cells, with reduced CDK2 kinase activity and increased p27 expression. These results suggest that Jagged-1 could be a potential therapeutic target for the treatment of prostate cancer. (c) 2006 Wiley-Liss, Inc.
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