期刊
INTERNATIONAL JOURNAL OF PHARMACEUTICS
卷 492, 期 1-2, 页码 275-290出版社
ELSEVIER SCIENCE BV
DOI: 10.1016/j.ijpharm.2015.06.004
关键词
Anionic cyclodextrins; Negatively charged; Carboxylate-; Sulfate-; Drug carriers; Cation binding
资金
- Marie Curie Program CYCLON (FP7-PEOPLE-ITN) [237962]
- Empirikion Foundation
- Marie Curie Program CycloN-Hit (FP7-PEOPLE-ITN) [608407]
The review presents a full library of single-isomer primary rim per-carboxylate-and per-sulfate-alpha-, -beta- and -gamma-cyclodextrin (CD) derivatives and their potential for pharmaceutical nanotechnology. Recent advances in cyclodextrin chemistry have enabled robust methods for the synthesis of single-isomer anionic CDs. Numerous nanobio-applications have been already reported for these negatively charged derivatives, which alone or in combination with other biodegradable molecular platforms can become important carriers for targeted drug delivery and release. Specialized applications are also discussed, such as chiral separations, as well as the ability of per-6-carboxylated-cyclodextrins to coordinate with metal cations and especially with lanthanide cations that makes them candidates as contrast agents for Magnetic Resonance Imaging. (C) 2015 Elsevier B.V. All rights reserved.
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