期刊
BRITISH JOURNAL OF CANCER
卷 95, 期 9, 页码 1131-1135出版社
NATURE PUBLISHING GROUP
DOI: 10.1038/sj.bjc.6603400
关键词
tumour microenvironment; bioactive lipid signaling; sphingosine-I-phosphate; lipodomics; angiogenisis
类别
This review summarises some important new findings that implicate sphingosine-1-phosphate (SIP) as a potent tumorigenic and angiogenic agent released from cancerous tumours into the tumour microenvironment. Also explored is the novel concept that bioactive lipid signalling molecules, like SIP, can themselves be targets for rational drug design, thereby opening up an entire class of lipidomic-based therapeutics for oncology and other human diseases.
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