期刊
NEUROREPORT
卷 17, 期 16, 页码 1683-1686出版社
LIPPINCOTT WILLIAMS & WILKINS
DOI: 10.1097/01.wnr.0000239954.60695.c6
关键词
Alzheimer's disease; apolipoprotein E; functional magnetic resonance imaging; memory; parietal cortex
Apolipoprotein E-epsilon 4 is the main known genetic risk factor for Alzheimer's disease. Functional abnormalities in the parietal cortex have been reported for Alzheimer's disease patients and also for those at risk. Hence, a critical question is whether measurements of parietal cortex integrity may predict negative outcome among at-risk persons. We studied nondemented apolipo-protein E-epsilon 4 carriers and found a significant relationship between parietal blood-oxygen-level-dependent functional magnetic resonance imaging response during a word categorization task and subsequent episodic memory performance. Thus, the results show that parietal cortex alterations predict memory decline in nondemented apolipoprotein E-epsilon 4 carriers, and hence likely progression to Alzheimer's disease.
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