期刊
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
卷 103, 期 45, 页码 16942-16947出版社
NATL ACAD SCIENCES
DOI: 10.1073/pnas.0606863103
关键词
disease protection; opsonophagocytosis; reverse vaccinology
资金
- NIAID NIH HHS [AI 38897, R01 AI052474, AI 52474, R01 AI038897] Funding Source: Medline
Staphylococcus aureus is the most common cause of hospital-acquired infection. Because of the emergence of anti biotic-resistant strains, these infections represent a serious public health threat. To develop a broadly protective vaccine, we tested cell wall-anchored surface proteins of S. aureus as antigens in a murine model of abscess formation. Immunization with four antigens (IsdA, IsdB, ScIrD, and SdrE) generated significant protective immunity that correlated with the induction of opsonophagocytic antibodies. When assembled into a combined vaccine, the four surface proteins afforded high levels of protection against invasive disease or lethal challenge with human clinical S. aureus isolates.
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