期刊
DRUG AND ALCOHOL DEPENDENCE
卷 85, 期 2, 页码 129-137出版社
ELSEVIER IRELAND LTD
DOI: 10.1016/j.drugalcdep.2006.04.002
关键词
cocaine; amantadine; propranolol; withdrawal; clinical trial; dopamine; norepinephrine; beta-blocker; medication adherence
资金
- NIDA NIH HHS [P50 DA12756] Funding Source: Medline
Background: This trial evaluated the efficacy of amantadine, propranolol and their combination in cocaine dependent patients with severe cocaine withdrawal symptoms. Methods: Cocaine withdrawal symptom severity was measured by the cocaine selective severity assessment (CSSA). One hundred and ninety-nine patients with high scores on the CSSA participated in a 10-week double-blind trial. Patients were randomly assigned to receive amantadine (300 mg/day), propranolol (100 mg/day), a combination of amantadine (300 mg/day) and propranolol (100 mg/day) or matching placebo capsules. The primary outcome measure was cocaine abstinence. Results: In the intent-to-treat sample, there were no significant differences between the four medication groups in treatment retention. The odds of cocaine abstinence showed a marginally significant increase over time in the propranolol group (p=0.06) but not in the other three groups. In highly medication-adherent patients, treatment retention was significantly better in the propranolol group compared to the placebo group (p=0.01) and the odds of cocaine abstinence increased significantly over time in the propranolol group but not in the other three groups. Conclusion: In the intent-to-treat sample, none of the three active treatments (propranolol, amantadine or their combination) was significantly more effective than placebo in promoting abstinence from cocaine among patients who entered treatment with more severe cocaine withdrawal symptoms. Among patients highly adherent to study medication, propranolol treatment was associated with better treatment retention and higher rates of cocaine abstinence compared to placebo. (c) 2006 Elsevier Ireland Ltd. All rights reserved.
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