期刊
VIROLOGY
卷 355, 期 1, 页码 1-5出版社
ACADEMIC PRESS INC ELSEVIER SCIENCE
DOI: 10.1016/j.virol.2006.08.009
关键词
HIV; superinfection; neutralizing antibody; vaccine; primary infection
类别
资金
- NIAID NIH HHS [AI36214, U01AI38858, AI043638, AI047745, AI27670, AI29164, 5K23 AI055276] Funding Source: Medline
Occurrences of HIV-1 superinfection offer a unique opportunity to investigate the correlates of immune protection. Here we describe the neutralizing antibody responses of a cohort of recently infected individuals who were screened for HIV superinfection. Three individuals identified with HIV superinfection had less cross-protective and autologous neutralizing antibody response than their non-superinfected casecontrols. Neutralizing antibody may be crucial in the protection against superinfection and may explain why superinfection has only been documented following recent infection or treatment interruption. These data have considerable implications for vaccine development. Published by Elsevier Inc.
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