期刊
SCIENCE
卷 314, 期 5801, 页码 982-985出版社
AMER ASSOC ADVANCEMENT SCIENCE
DOI: 10.1126/science.1133276
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资金
- NIAMS NIH HHS [K08-AR02179] Funding Source: Medline
The molecular mechanisms controlling human hair growth and scalp hair loss are poorly understood. By screening about 350,000 individuals in two populations from the Volga-Ural region of Russia, we identified a gene mutation in families who show an inherited form of hair loss and a hair growth defect. Affected individuals were homozygous for a deletion in the LIPH gene on chromosome 3q27, caused by short interspersed nuclear element - retrotransposon - mediated recombination. The LIPH gene is expressed in hair follicles and encodes a phospholipase called lipase H ( alternatively known as membrane-associated phosphatidic acid - selective phospholipase A1 alpha), an enzyme that regulates the production of bioactive lipids. These results suggest that lipase H participates in hair growth and development.
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