期刊
FEBS LETTERS
卷 580, 期 26, 页码 6259-6268出版社
ELSEVIER SCIENCE BV
DOI: 10.1016/j.febslet.2006.10.028
关键词
CRSBP-1; LYVE-1; CRSBP-1/LYVE-1 null mice; PDGF; PDGF-BB; HA; distended lumens; interstitial-lymphatic flow
资金
- NCI NIH HHS [R01 CA038808-18S1, CA38808, R01 CA038808] Funding Source: Medline
- NIAMS NIH HHS [R43 AR052578-01A1, R43 AR052578] Funding Source: Medline
CRSBP-1, a membrane glycoprotein, can mediate cell-surface retention of secreted growth factors containing CRS motifs such as PDGF-BB. CRSBP-1 has recently been found to be identical to LYVE-I, a specific marker for lymphatic capillary endothelial cells. The in vivo role of CRSBP-1/LYVE-1 is unknown. CRSBP-1-null mice are overtly normal and fertile but exhibit identifiable morphological and functional alterations of lymphatic capillary vessels in certain tissues, marked by the constitutively increased interstitial-lymphatic flow and lack of typical irregularly-shaped lumens. The CRSBP-I ligands DGF-BB and HA enhance interstitial-lymphatic How in wildtype mice but not in CRSBP-1-null animals. (c) 2006 Federation of European Biochemical Societies. Published by Elsevier B.V. All rights reserved.
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