A protein kinase signal-responsive gene carrier modified RGD peptide

We have previously reported artificial gene-regulation systems responding to cyclic AMP-dependent protein kinase (PKA) using a cationic polymer. However, this polymer alone cannot deliver any gene into living cells. In the present work, we modified the signal-responsive polymer to the RGD peptide for the introduction of a polyrner/DNA complex into living cells and succeeded in regulating the gene expression responding to intracellular PKA activation. (c) 2006 Elsevier Ltd. All rights reserved.