期刊
GLIA
卷 54, 期 7, 页码 700-715出版社
WILEY
DOI: 10.1002/glia.20367
关键词
Ca2+ excitability; exocytosis; glutamate; ATP; SNARE proteins; vesicle; synapse
资金
- NIMH NIH HHS [R01 MH 69791] Funding Source: Medline
Astrocytes can release a variety of transmitters, including glutamate and ATP, in response to stimuli that induce increases in intracellular Ca2+ levels. This release occurs via a regulated, exocytotic pathway. As evidence of this, astrocytes express protein components of the vesicular secretory apparatus, including synaptobrevin 2, syntaxin, and SNAP-23. Additionally, astrocytes possess vesicular organelles, the essential morphological elements required for regulated Ca2+-dependent transmitter release. The location of specific exocytotic sites on these cells, however, remains to be unequivocally determined. (c) 2006 Wiley-Liss, Inc.
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