期刊
JOURNAL OF BIOLOGICAL CHEMISTRY
卷 281, 期 46, 页码 34973-34981出版社
AMER SOC BIOCHEMISTRY MOLECULAR BIOLOGY INC
DOI: 10.1074/jbc.M607018200
关键词
-
The members of the NF-kappa B transcription factor family are key regulators of gene expression in the immune response. Different combinations of NF-kappa B subunits not only diverge in timing to induce transcription but also recognize varying sequences of the NF-kappa B-binding site of their target genes. The p52 subunit is generated as a result of processing of NF-kappa B2 p100. Here, we demonstrate that the non-canonical I kappa B kinase is an element of(IKK is an element of) directly interacts with p100. In a transactivation assay, IKK is an element of promoted the ability of p52 to transactivate gene expression. This effect was indirect, requiring p65, which was shown to be part of the IKK is an element of-p52 complex and to be phosphorylated by IKK is an element of. These novel interactions reveal a hitherto unknown function of IKK is an element of in the regulation of the alternative NF-kappa B activation pathway involving p52 and p65.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据