期刊
ORGANIC PROCESS RESEARCH & DEVELOPMENT
卷 10, 期 6, 页码 1172-1177出版社
AMER CHEMICAL SOC
DOI: 10.1021/op0601316
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The reaction engineering of benzaldehyde lyase (BAL, E.C. 4.1.2.38) from Pseudomonas fluorescens catalyzing the enantioselective carboligation of benzaldehyde and acetaldehyde yielding (R)-2-hydroxy-1-phenylpropanone (HPP) is presented. Based on kinetic studies a continuous process is developed. The developed bioreactor allows focusing the complex reaction system on the production of HPP with simultaneous discrimination of the undesired benzoin formation. The application of a continuous process in combination with membrane technology enables high space time yields (1120 g L-1 d(-1), ee > 99%) of the product as well as high total turnover numbers of the biocatalyst (mol of product/mol of biocatalyst = 188.000). A kinetic model was developed to simulate the continuously operated reactor and to determine optimal production conditions. The synthesis of (R)-(3-chlorophenyl)-2-hydroxy-1-propanone (1214 g L-1 d(-1), ee = 99%) in the bioreactor demonstrates a broad applicability of the presented reactor concept for the production HPP derivatives.
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