期刊
JOURNAL OF CHROMATOGRAPHY A
卷 1134, 期 1-2, 页码 88-94出版社
ELSEVIER SCIENCE BV
DOI: 10.1016/j.chroma.2006.08.073
关键词
molecularly imprinted polymer; nicotine; precipitation polymerization; chiral separation; molecular recognition; cigarette smoke extract
Uniformly-sized, molecularly imprinted polymers (MIPs) for (S)-nicotine have been prepared by a precipitation polymerization method using methacrylic acid (MAA) or 2-(trifluoromethyl)acrylic acid (TFMAA) as a functional monomer and divinylbenzene (DVB) as a cross-linker in a mixture of toluene and acetonitrile. The (S)-nicotine-imprinted MAA-co-DVB polymers were monodispersed microspheres of about 4 mu m in diameter, while the TFMAA-co-DVB ones were gel-like. Molecular recognition abilities of the former MIPs were evaluated for nicotine and its structurally related compounds in liquid chromatography using a mixture of sodium phosphate buffer and acetonitrile as the eluent. Enantioseparation of nicotine was attained using the (S)-nicotine-imprinted MAA-co-DVB polymers. Furthermore, they could selectively trap nicotine in cigarette smoke extracts. (c) 2006 Elsevier B.V. All rights reserved.
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