期刊
CELL
卷 127, 期 4, 页码 735-745出版社
CELL PRESS
DOI: 10.1016/j.cell.2006.09.038
关键词
-
资金
- NIGMS NIH HHS [R01 GM35010-23, R01 GM040266-23, 5F32GM077738] Funding Source: Medline
Entry into meiosis is a key developmental decision. We show here that meiotic entry in Saccharomyces cerevisiae is controlled by antisense-mediated regulation of IME4, a gene required for initiating meiosis. In MATa/alpha diploids the antisense IME4 transcript is repressed by binding of the a1/alpha 2 heterodimer at a conserved site located downstream of the IME4 coding sequence. MAT a/alpha diploids that produce IME4 antisense transcript have diminished sense transcription and fail to initiate meiosis. Haploids that produce the sense transcript have diminished antisense transcription and manifest several diploid phenotypes. Our data are consistent with transcription interference as a regulatory mechanism at the IME4 locus that determines cell fate.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据