期刊
CANCER LETTERS
卷 243, 期 2, 页码 274-280出版社
ELSEVIER IRELAND LTD
DOI: 10.1016/j.canlet.2005.11.031
关键词
honokiol; P-glycoprotein; drug resistance
类别
P-glycoprotein accounts for the most intrinsic and acquired cancer multidrug resistance. To inhibit the expression of P-glycoprotein is one of the effective ways to reverse cancer drug resistance. Honokiol, a naturally occurring compound, has been demonstrated to combat cancer through mechanisms including inhibition of angiogenesis and induction of apoptosis. Here, we show that honokiol down-regulated the expression of P-glycoprotein at mRNA and protein levels in MCF-7/ADR, a human breast MDR cancer cell line. The down-regulation of P-glycoprotein was accompanied with a partial recovery of the intracellular drug accumulation, and of the sensitivities toward adriamycin. This study reveals a novel function of honokiol as an anti-cancer agent. (c) 2005 Elsevier Ireland Ltd. All rights reserved.
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