Spontaneous transfer of phospholipid-coated oil-in-oil and water-in-oil micro-droplets through an oil/water interface

We studied the evolution of oil-in-oil (O/O) and water-in-oil (W/O) phospholipid-coated micro-droplets at an oil/water interface. We found that, in both cases, micro-droplets spontaneously transferred from the oil phase to the water phase.O/O micro-droplets transformed into oil-in-water micro-droplets, while W/O micro-droplets led to the formation of liposomes.