期刊
NEURON
卷 52, 期 4, 页码 649-661出版社
CELL PRESS
DOI: 10.1016/j.neuron.2006.10.007
关键词
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资金
- Medical Research Council [G0501572, MC_U117512674] Funding Source: Medline
- Wellcome Trust Funding Source: Medline
- Medical Research Council [MC_U117512674, G0501572] Funding Source: researchfish
- MRC [MC_U117512674, G0501572] Funding Source: UKRI
The expression mechanism of long-term potentiation (LTP) remains controversial. Here we combine electrophysiology and Ca2+ imaging to examine the role of silent synapses in LTP expression. Induction of LTP fails to change p(r) at these synapses but instead mediates an unmasking process that is sensitive to the inhibition of postsynaptic membrane fusion. Once unmasked, however, further potentiation of formerly silent synapses leads to an increase in p(r). The state of the synapse thus determines how LTP is expressed.
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