期刊
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
卷 128, 期 46, 页码 14986-14991出版社
AMER CHEMICAL SOC
DOI: 10.1021/ja065507+
关键词
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A simple approach for the formation of optically active highly functionalized tetrahydrothiophenes, which might find important use in biochemistry, pharmaceutical science, and nanoscience is presented. Development of new organocatalytic Michael-aldol domino reactions is outlined, and with the appropriate choice of additives it is possible to control the regioselectivity of these domino reactions, yielding diastereomerically pure ( tetrahydrothiophen-2-yl) phenyl methanones or tetrahydrothiophene carbaldehydes in good yields and with excellent enantioselectivities up to 96% ee. The stereochemical outcome of these reactions is investigated, and the mechanism of these organocatalytic domino processes is presented.
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