期刊
BEHAVIOURAL BRAIN RESEARCH
卷 175, 期 1, 页码 189-194出版社
ELSEVIER SCIENCE BV
DOI: 10.1016/j.bbr.2006.08.009
关键词
dopamine transporter; scrotonin transporter; norepinephrine transporter; psychostimulant; self-administration; addiction; monoamine; relapse; reinstatement
Reinstatement of cocaine-seeking behavior can be elicited by a systemic priming injection of cocaine or a non-selective biogenic amine transporter inhibitor. In order to determine which biogenic amine is responsible for this effect, selective dopamine (G]BR 12909), serotonin (fluoxetine) or norepinephrine (nisoxetine) transporter inhibitors were systemically administered in order to assess their ability to induce cocaine seeking in rats. Administration of GBR 12909, but not nisoxetine or fluoxetine, dose-dependently reinstated cocaine seeking in rats. Furthermore, administration of the non-selective dopamine receptor antagonist flupenthixol into the nucleus accumbens shell attenuated GBR 12909-induced reinstatement of cocaine seeking. These results suggest that increases in extracellular concentrations of dopamine, specifically in the nucleus accumbens shell, are primarily responsible for promoting cocaine priming-induced reinstatement of drug seeking in rats. (c) 2006 Elsevier B.V. All rights reserved.
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