Synthesis of dispirooxindolecycloalka[d]pyrimidino[2,3-b]-thiazole pyrrolidine/thiapyrrolizidine ring systems

The synthesis of a new class of spirooxindolo pyrrolidines and spirooxindolo thiapyrrolizidines has been accomplished by a three component, one-pot 1,3-dipolar cycloaddition reaction. The cycloaddition was found to be highly regioselective. (c) 2006 Elsevier Ltd. All rights reserved.