NBS as an efficient catalyst for the synthesis of 1,5-benzodiazepine derivatives under mild conditions

Various biologically important 1,5-benzodiazepine derivatives were efficiently synthesized in excellent yields using catalytic amounts of NBS (10 mol %). This inexpensive, nontoxic, and readily available catalyst efficiently catalyzes the condensation of several aromatic as well as aliphatic ketones with substituted o-phenylenediamines. (c) 2006 Published by Elsevier Ltd.