期刊
JOURNAL OF NATURAL PRODUCTS
卷 69, 期 11, 页码 1649-1652出版社
AMER CHEMICAL SOC
DOI: 10.1021/np060418w
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资金
- NCI NIH HHS [U19 CA052956-15, U19 CA052956, U19-CA-52956] Funding Source: Medline
Five new prenylated flavonoids (1-5) were isolated from the root bark of Berchemia discolor, collected in Tanzania, along with 10 known compounds, by bioactivity-guided fractionation. The structures of compounds 1-5 were elucidated using various spectroscopic techniques. Of these isolates, compound 4, and the known compounds nitidulin (6), amorphigenin (7), and dabinol (8), exhibited cytotoxic activity when evaluated against a small panel of human cancer cells. Nitidulin (6) was further tested in an in vivo hollow fiber assay and found to be active against LNCaP (human hormone-dependent prostate cancer) cells implanted intraperitoneally, at doses of 10, 20, and 40 mg/kg.
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