期刊
BRAIN RESEARCH
卷 1122, 期 -, 页码 27-35出版社
ELSEVIER
DOI: 10.1016/j.brainres.2006.08.113
关键词
nicotinic receptor; bungarotoxin; inbred mouse strain; DBA/2; C3H; genetic
资金
- NIDA NIH HHS [DA014369] Funding Source: Medline
- NIMH NIH HHS [MH068582, 5 P50 MH068582] Funding Source: Medline
The time course and pattern of development of hippocampal alpha 7 nicotinic acetylcholine receptors is discernibly different in OH and DBA/2 mice. In OH mice, the alpha 7 receptor is initially expressed on embryonic day 13, exhibits an increase in density in area CA1 perinatally and is characterized by a dense, diffuse band of a-bungarotoxin binding at the CA3/CA1 border in the adult. In contrast, the alpha 7 receptor is initially expressed on embryonic day 16 in DBA/2 mice, does not exhibit a transient perinatal increase in binding density in area CA1 and is characterized by alpha-bungarotoxin binding to numerous Nissl-stained structures in CA1 lacunosum/moleculare in the adult. Currently, it is not known whether these developmental differences occur solely as a result of the different alleles of the alpha 7 receptor gene (Chrna7) expressed by the two strains or whether strain-specific background factors also play a role. The present study qualitatively examines this question by comparing alpha 7 receptor development in congenic mice in which the DBA/2 allele of Chrna7 has been introgressed onto a C3H genetic background and, conversely, the C3H allele of Chrna7 has been introgressed onto a DBA/2 genetic background. The data suggest that hippocampal alpha 7 receptor development is controlled predominantly by a region of mouse chromosome 7 that contains the strain-specific Chrna7 allele. (c) 2006 Elsevier B.V. All rights reserved.
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