期刊
PHYSIOLOGY & BEHAVIOR
卷 89, 期 4, 页码 525-530出版社
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.physbeh.2006.03.021
关键词
sucrose; saccharin; mice; strain differences; C57BL/6J; 129P3/J; intragastric conditioning; operant licking
资金
- Intramural NIH HHS [Z01 DK031135] Funding Source: Medline
- NIDDK NIH HHS [R37 DK031135-23, DK59360, R01 DK031135, R37 DK031135] Funding Source: Medline
Inbred mouse strains differ in their preferences for sweeteners, due in part to variations in their T1R3 sweet taste receptor. Recent studies of sweet sensitive C57BL/6J (B6) and subsensitive 129P3/J (129) mice indicate that experiential and post-oral effects of sugar substantially modify sweetener preference. In fact, the strain difference in sucrose preference disappeared after the mice were given 23 h/day tests with sucrose at ascending concentrations (0.5-32%). Intragastric infusions of sucrose (16%) also conditioned increased preference for and absolute intake of flavored sweet solutions in B6 and 129 mice. An operant analysis of sweetener appetite revealed, unexpectedly, that sugar-experienced 129 mice respond more vigorously than B6 mice for 16% sucrose rewards. These findings indicate that experiential and nutritional factors can, to some degree, override genetic differences in peripheral taste sensitivity in determining food appetite. (c) 2006 Elsevier Inc. All rights reserved.
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