期刊
PHYSIOLOGY & BEHAVIOR
卷 89, 期 4, 页码 531-535出版社
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.physbeh.2006.05.024
关键词
dopamine; parabrachial nucleus; sucrose; taste
资金
- NIDCD NIH HHS [R01 DC000240, DC05435, R01 DC005435, R01 DC000240-24, R01 DC005435-03, DC00240] Funding Source: Medline
- NIDDK NIH HHS [R01 DK065709-03, R01 DK065709, DK065709] Funding Source: Medline
The concept of reward is central to psychology, but remains a cipher for neuroscience. Considerable evidence implicates dopamine in the process of reward and much of the data derives from the nucleus accumbens. Gustatory stimuli are widely used for animal studies of reward, but the connections between the taste and reward systems are unknown. In a series of experiments, our laboratory has addressed this issue using functional neurochemistry and neuroanatomy. First, using microdialysis probes, we demonstrated that sapid sucrose releases dopamine in the nucleus accumbens. The effect is dependent on oral stimulation and concentration. We subsequently determined that this response was independent of the thalamocortical gustatory system, but substantially blunted by damage to the parabrachial limbic taste projection. Further experiments using c-fos histochemistry confirmed that the limbic pathway was the prime carrier for the gustatory afferent activity that drives accumbens dopamine release. (c) 2006 Elsevier Inc. All rights reserved.
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