期刊
BIOCHEMICAL PHARMACOLOGY
卷 72, 期 11, 页码 1570-1576出版社
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.bcp.2006.06.034
关键词
major histocompatibility complex class II; class II transactivator; cancer; gene regulation; DNA methylation; histone modification
Lack of expression of major histocompatibility complex (MHC) molecules of both classes is frequently noted on tumour cells [1]. It is thought that in this way tumour cells escape immunosurveillance. The genes encoding both classes of MHC molecules are localized on the distal part of chromosome 6 (6p21.3). The class II transactivator (CIITA), encoded by the MHC2TA gene, is essential for transcriptional activation of all MHC-II genes, while it has a helper function in the transcriptional regulation of MHC-I genes (with the exception of human leukocyte antigen (HLA)-G) and of the gene encoding beta 2-microglobulin (beta 2m) [2]. Here we discuss our current knowledge on the expression characteristics of MHC2TA and argue for an important role of epigenetic factors and mechanisms in the transcriptional silencing of MHC2TA in cancer cells. (c) 2006 Elsevier Inc. All rights reserved.
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