期刊
STATISTICS IN MEDICINE
卷 25, 期 22, 页码 3769-3786出版社
JOHN WILEY & SONS LTD
DOI: 10.1002/sim.2494
关键词
missing data; multiple imputations; software; Bayesian methods; verification bias
类别
资金
- NIMH NIH HHS [K01 MH087219] Funding Source: Medline
In the case in which all subjects are screened using a common test and only a subset of these subjects are tested using a golden standard test, it is well documented that there is a risk for bias, called verification bias. When the test has only two levels (e.g. positive and negative) and we are trying to estimate the sensitivity and specificity of the test, we are actually constructing a confidence interval for a binomial proportion. Since it is well documented that this estimation is not trivial even with complete data, we adopt multiple imputation framework for verification bias problem. We propose several imputation procedures for this problem and compare different methods of estimation. We show that our imputation methods are better than the existing methods with regard to nominal coverage and confidence interval length. Copyright (c) 2006 John Wiley & Sons, Ltd.
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