期刊
JOURNAL OF ALZHEIMERS DISEASE
卷 10, 期 4, 页码 391-397出版社
IOS PRESS
关键词
redox proteomics; familial Alzheimer's disease; oxidatively modified brain proteins
资金
- NIA NIH HHS [AG-10836, AG-05119] Funding Source: Medline
Objective: To identify oxidatively modified proteins in brains of persons with inherited Alzheimer's disease. Methods: Redox proteomics was used to identify oxidatively modified brain proteins in persons with mutations in the genes for presenilin-1 (PS-1). Results: An initial redox proteornics assessment of oxidatively modified proteins from brains of individuals with PS-1 mutations was performed. These PS-1 mutations, Q222H and M233T, are completely penetrant causing early-onset familial AD as, previously reported in these Australian families. We show that oxidative modifications of ubiquitin carboxyl-terminal hydrolase L1 (UCH-LI), gamma-enolase, actin, and dimethylarginine dimethylarninohydrolase 1 (DMDMAH-1) are present in the brain of familial AD subjects. Conclusions: These initial results suggest that oxidatively modified proteins are important common features in both familial and sporadic AD.
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