期刊
TRENDS IN BIOCHEMICAL SCIENCES
卷 31, 期 12, 页码 694-699出版社
ELSEVIER SCIENCE LONDON
DOI: 10.1016/j.tibs.2006.10.003
关键词
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资金
- NIGMS NIH HHS [R37 GM028140, GM 28140, R01 GM028140] Funding Source: Medline
Phosphatidate phosphatase (PAP) enzymes catalyze the dephosphorylation of phosphatidate, yielding diacylglycerol and inorganic phosphate. In eukaryotic cells, PAP activity has a central role in the synthesis of phospholipids and triacylglycerol through its product diacylglycerol, and it also generates and/or degrades lipid-signaling molecules that are related to phosphatidate. There are two types of PAP enzyme, Mg2+ dependent (PAP1) and Mg2+ independent (PAP2), but only genes encoding PAP2 enzymes had been identified until recently, when a gene (PAH1) encoding a PAN enzyme was found in Saccharomyces cerevisiae. This discovery has revealed a molecular function of the mammalian protein lipin, a deficiency of which causes lipodystrophy in mice. With molecular information now available for both types of PAP, the specific roles of these enzymes in lipid metabolism are being clarified.
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