期刊
JOURNAL OF CELLULAR BIOCHEMISTRY
卷 99, 期 5, 页码 1442-1451出版社
WILEY-LISS
DOI: 10.1002/jcb.21034
关键词
gangliosides; EGF receptor; ganglioside glycosyltransferase; skin; mice; glycolipid
We studied in this work the in vivo phosphorylation of the epidermal growth factor receptor (EGFr) in skin from knockout mice lacking different ganglioside glycosyltransferases. Results show an enhancement of EGFr phosphorylation, after EGF stimulation, in skin from Sial-T2 knockout and Sial-T2/GaINAc-T double knockout mice as compared with wild-type and Sial-Ti knockout mice. Qualitative analysis of ganglioside composition in mice skin suggest that the increase of EGFr phosphorylation observed in skin from Sial-T2 knockout and Sial-T2/Gal NA&T double knockout mice in response to EGF might not be primary attributed to the expression of GD3 or a-series gangliosides in mice skin. These studies provide, for the first time, an approach for studying the molecular mechanisms involved in the in vivo regulation of EGFr function by gangliosides. J. Cell. Biochem. 99: 1442-1451, 2006. (c) 2006 Wiley-Liss, Inc.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据